Natural phytochemicals as P2X7 receptor inhibitors for the treatment of inflammation-related diseases
نویسندگان
چکیده
P2X7 receptor (P2X7R) inhibition is critical for reducing the overactivation of its downstream signaling pathway in autoimmune diseases. Phytochemicals are a source medicinal compounds various diseases and contribute to development effective safe P2X7R-targeted drugs. This review aimed at identifying screening novel safe, effective, economically feasible inhibitors P2X7R from phytochemicals extracted food plants. The results docking study revealed that VINA scores dihydrotanshinone, baicalin, berberine, genistin, dioscin, resveratrol, apigenin, cannabidiol, esculin, luteolin were lower than or equal A740003 (P2X7R inhibitor). dihydrotanshinone baicalin JNJ47965567 Dihydrotanshinone can be used as lead inhibition. These active ingredients will discovery innovative agents treatment
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ژورنال
عنوان ژورنال: Italian Journal of Food Science
سال: 2023
ISSN: ['2239-5687', '1120-1770']
DOI: https://doi.org/10.15586/ijfs.v35i2.2288